DMBT1
Sign in to saveAlso known as GP340, muclin, SAG, deleted in malignant brain tumors 1, SALSA
Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.
Gene data
DMBT1- Name
- deleted in malignant brain tumors 1
- Type
- protein-coding
- Aliases
- GP340, SAG, SALSA, muclin
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Mar 2016].
via MyGene.info
Gene · Ensembl
deleted in malignant brain tumors 1
- Symbol
- DMBT1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:122,560,641-122,643,740
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~3 min read
Encyclopedic overview
5 sectionsContents
- Function
- Pattern recognition and potential use of DMBT1 in nanomedicine
- Interactions
- References
- Further reading
Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.
== Function ==
Excerpted from Wikipedia’s “DMBT1” article, available under the CC BY-SA 4.0 licence.