DNQX

DNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies. It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.

Research

1,155 papers

DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference.Brain research · 1995
DNQX-induced toxicity in cultured rat hippocampal neurons: an apparent AMPA receptor-independent effect?Neurochemistry international · 2003
Selective excitatory actions of DNQX and CNQX in rat thalamic neurons.Journal of neurophysiology · 2010
Aniracetam and DNQX affect the acquisition of rapid tolerance to ethanol in mice.Pharmacology, biochemistry, and behavior · 2009
DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex.Brain research · 1995

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Wikidata facts

Mass: 249.997

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chemical formula: C₈H₂N₄O₆
canonical SMILES: C1=C(C(=CC2=NC(=O)C(=O)N=C21)[N+](=O)[O-])[N+](=O)[O-]
Commons category: DNQX

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Article

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DNQX (an AMPA receptor antagonist) displays significant effects on neurons. When applied to rat hippocampus neurons in culture, it produces a dose-dependent neurotoxicity which intriguingly seems to operate through a mechanism independent of ionotropic glutamate receptors. This effect is specific to neurons and does not impact the surrounding glial cells.