dopamine beta-hydroxylase

Protein · UniProt

Dopamine beta-hydroxylase

Gene

DBH

Organism

Homo sapiens (Human)

Length

617 aa

Molecular mass

69,065 Da

Evidence

1: Evidence at protein level

Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters

• DOPAMINE-BETA-HYDROXYLASE.Pharmacological reviews · 1965
• Congenital dopamine-beta-hydroxylase deficiency in humans.Annals of the New York Academy of Sciences · 2004
• [Dopamine-beta-hydroxylase].Nihon rinsho. Japanese journal of clinical medicine · 2005
• Dopamine-beta-hydroxylase.Journal of psychiatric research · 1974
• Serum dopamine beta-hydroxylase.Pharmacological reviews · 1978

via PubMed

• PHASE2COMPLETED
  Pharmacogenetics of Disulfiram for CocaineBaylor College of Medicine · NCT00149630
• PHASE3COMPLETED
  A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using DroxidopaChelsea Therapeutics · NCT00782340
• APPROVED_FOR_MARKETING
  Long Term Treatment With L-DOPSVanderbilt University · NCT00889135
• PHASE3COMPLETED
  Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)Chelsea Therapeutics · NCT00738062
• PHASE4WITHDRAWN
  A PET Exploration of the Mechanism of Action of Dopamine Beta-hydroxylase Inhibition in Cocaine AddictsAssistance Publique - Hôpitaux de Paris · NCT02134002
• PHASE3TERMINATED
  A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa TherapyChelsea Therapeutics · NCT01927055

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

via Wikidata · CC0