doxapram
Also known as AHR-619, Dopram®, (+-)-doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone, (+-)-Doxapram, 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone, Doxapramum
Doxapram is a respiratory stimulant, or analeptic. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
Chemical data
- Formula
- C24H30N2O2
- Molecular weight
- 378.5 g/mol
- IUPAC name
- 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one
- SMILES
- CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4
- InChIKey
- XFDJYSQDBULQSI-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 32.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
698 papersArticle
6 sectionsContents
- Medical uses
- Side effects
- Mechanism of action
- Appearance
- See also
- References
Doxapram is a respiratory stimulant, or analeptic. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
==Medical uses== Doxapram is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as opioids which may fail to respond adequately to treatment with naloxone.