drospirenone

Also known as dihydrospirorenone, Yasmin®, ZK30595, Dehydrospirorenone, 6beta,7beta;15beta,16beta-Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone, 1,2-Dihydrospirorenone, 6β,7β,15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17 carbolactone

Drospirenone is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy and in menopausal hormone therapy, among other uses. It is available both alone under the brand name Slynd and in combination with an estrogen under the brand name Yasmin among others. The medication is an analog of the drug spironolactone. Drospirenone is taken by mouth.

Key facts

Drug.Verifiedfields: verified
Drug.Watchedfields: verified
Drug.verifiedrevid: 443713428
Drug.image: Drospirenone.svg
Drug.image_class: skin-invert-image
Drug.width: 225
Drug.image2: Drospirenone molecule ball.png
Drug.image_class2: bg-transparent
Drug.width2: 225
Drug.pronounce: Droe-SPY-re-nown
Drug.tradename: Alone: SlyndWith estradiol: AngeliqWith ethinylestradiol: Yasmin, Yasminelle, Yaz, othersWith estetrol: Nextstellis
Drug.DailyMedID: Drospirenone
Drug.routes_of_administration: By mouth
Drug.class: Progestogen; Progestin; Antimineralocorticoid; Steroidal antiandrogen
Drug.ATC_prefix: G03
Drug.ATC_suffix: AC10
Drug.ATC_supplemental: (combinations with estrogens)
Drug.legal_AU: S4

via Wikipedia infobox

Research

1,156 papers

Estetrol/Drospirenone: A Review in Oral Contraception.Drugs · 2022
Oral contraceptives containing drospirenone for premenstrual syndrome.The Cochrane database of systematic reviews · 2023
Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen.Women's health (London, England) · 2023
Estetrol/Drospirenone safety in a population with cardiovascular risk factors.Contraception · 2025
Drospirenone/ethinyl estradiol.Drugs of today (Barcelona, Spain : 1998) · 2008

via PubMed

Wikidata facts

Mass: 366.219

Show 5 more facts

chemical formula: C₂₄H₃₀O₃
canonical SMILES: CC12CCC(=O)C=C1C3CC3C4C2CCC5(C4C6CC6C57CCC(=O)O7)C
isomeric SMILES: C[C@]12CCC(=O)C=C1[C@@H]3C[C@@H]3[C@@H]4[C@@H]2CC[C@]5([C@H]4[C@@H]6C[C@@H]6[C@@]57CCC(=O)O7)C
World Health Organisation international non-proprietary name: drospirenone
Commons category: Drospirenone

Sources (3)

via Wikidata · CC0

~26 min read

Article

31 sections

Contents

Medical uses
Available forms
Contraindications
Side effects
High potassium levels
Blood clots
Breast cancer
Overdose
Interactions
Pharmacology
Pharmacodynamics
Progestogenic activity
Antimineralocorticoid activity
Antiandrogenic activity
Other activity
Pharmacokinetics
Absorption
Distribution
Metabolism
Elimination
Chemistry
History
Society and culture
Generic names
Brand names
Availability
Generation
Litigation
Research
References
Further reading

Common side effects include acne, headache, breast tenderness, weight increase, and menstrual changes. Rare side effects may include high potassium levels and blood clots (when taken as a combined oestrogen-progestogen pill), among others. Drospirenone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has additional antimineralocorticoid and antiandrogenic activity and no other important hormonal activity. Because of its antimineralocorticoid activity and lack of undesirable off-target activity, drospirenone is said to more closely resemble bioidentical progesterone than other progestins.