Structure via PubChem · Public domain (PubChem)
DU-24565
Sign in to saveAlso known as DU24565, 6-nitroquipazine, DU-24,565
6-Nitroquipazine (developmental code name DU-24,565) is a potent and selective serotonin reuptake inhibitor used in scientific research.
Chemical data
- Formula
- C13H14N4O2
- Molecular weight
- 258.28 g/mol
- IUPAC name
- 6-nitro-2-piperazin-1-ylquinoline
- SMILES
- C1CN(CCN1)C2=NC3=C(C=C2)C=C(C=C3)[N+](=O)[O-]
- InChIKey
- GGDBEAVVGFNWIA-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 74 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
73 papers- Du 24565, a quipazine derivative, a potent selective serotonin uptake inhibitor.European journal of pharmacology · 1981
- Effects of DU 24565 (6-nitroquipazine) on serotoninergic and noradrenergic neurones of the rat brain and comparison with the effects of quipazine.Naunyn-Schmiedeberg's archives of pharmacology · 1984
- Inhibition of melanization in human melanoma cells by a serotonin uptake inhibitor.The Journal of investigative dermatology · 1987
- Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex.Naunyn-Schmiedeberg's archives of pharmacology · 1985
- In vivo labeling of 5-hydroxytryptamine uptake sites in mouse brain with [3H]-6-nitroquipazine.The Journal of pharmacology and experimental therapeutics · 1990
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 258.112
Show 4 more facts
- Commons category
- 6-Nitroquipazine
- chemical formula
- C₁₃H₁₄N₄O₂
- canonical SMILES
- C1CN(CCN1)C2=NC3=C(C=C2)C=C(C=C3)[N+](=O)[O-]
- subject has role
- serotonin antagonist
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
6-Nitroquipazine (developmental code name DU-24,565) is a potent and selective serotonin reuptake inhibitor used in scientific research.
6-Nitroquipazine has been found to inhibit melanogenesis in-vitro, suggesting that it can be used for skin whitening.
Excerpted from Wikipedia’s “DU-24565” article, available under the CC BY-SA 4.0 licence.