Structure via PubChem · Public domain (PubChem)
elbasvir
Sign in to saveAlso known as mk-8742, carbamic acid, n,n'-(((6s)-6-phenyl-6h-indolo(1,2-c)(1,3)benzoxazine-3,10-diyl)bis(1h-imidazole-5,2-diyl-(2s)-2,1-pyrrolidinediyl((1s)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl)))bis-, c,c'-dimethyl ester, elbasvir component of zepatier, zepatier component of elbasvir
Elbasvir is a drug approved by the FDA in January 2016 for the treatment of hepatitis C. It was developed by Merck and completed Phase III trials, used in combination with the NS3/4A protease inhibitor grazoprevir under the trade name Zepatier, either with or without ribavirin.
In the Vinony graph
Within Vinony's link graph, elbasvir is referenced by 103 other articles, and connects out to elbasvir/grazoprevir, influenza and digital object identifier.
It is catalogued under topics including Carbamates, Drug has EMA link and Drugs with non-standard legal status.
Its subject is documented across 10 Wikipedia language editions.
Chemical data
- Formula
- C49H55N9O7
- Molecular weight
- 882 g/mol
- IUPAC name
- methyl N-[(2S)-1-[(2S)-2-[5-[(6S)-3-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazin-10-yl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2016
- Admin. routes
- oral
- Indications
- viral human hepatitis infection, chronic hepatitis C virus infection, hepatitis C virus infection, viral disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 881.422445
- Has use
- medication
Show 4 more facts
- chemical formula
- C₄₉H₅₅N₉O₇
- canonical SMILES
- CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC4=C(C=C3)N5C(OC6=C(C5=C4)C=CC(=C6)C7=CN=C(N7)C8CCCN8C(=O)C(C(C)C)NC(=O)OC)C9=CC=CC=C9)NC(=O)OC
- isomeric SMILES
- CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC4=C(C=C3)N5[C@@H](OC6=C(C5=C4)C=CC(=C6)C7=CN=C(N7)[C@@H]8CCCN8C(=O)[C@H](C(C)C)NC(=O)OC)C9=CC=CC=C9)NC(=O)OC
- Commons category
- Elbasvir
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Side effects
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- References
{{Drugbox | IUPAC_name = Dimethyl N,N’-([(6S)-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{1H-imidazole-5,2-diyl-(2S)-pyrrolidine-2,1-diyl[(2S)-1-oxo-3-methylbutane-1,2-diyl]})biscarbamate | image = File:Elbasvir.svg | image_class = skin-invert-image | width = 350
| tradename = Zepatier (combination with grazoprevir) | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | licence_EU = yes | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = Oral
Excerpted from Wikipedia’s “elbasvir” article, available under the CC BY-SA 4.0 licence.
Available in 10 languages
via Wikidata sitelinks · CC0