EXOC2
Sign in to saveAlso known as SEC5, SEC5L1, Sec5p, exocyst complex component 2, NEDFACH
Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.
Gene data
EXOC2- Name
- exocyst complex component 2
- Type
- protein-coding
- Position
- 485,133–693,169 (−)
- Aliases
- NEDFACH, SEC5, SEC5L1, Sec5p
- Ensembl
- ENSG00000112685
- RefSeq RNA
- NM_018303.6, NR_073064.2, XM_017011022.2, XM_017011023.2, XM_017011024.2
- RefSeq protein
- NP_060773.3, XP_016866511.1, XP_016866512.1, XP_016866513.1, XP_016866514.1
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
exocyst complex component 2
- Symbol
- EXOC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:485,133-693,170
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein EXOC2 PDB 1hk6.png
Show 5 more facts
- HomoloGene ID
- 10122
- exact match
- identifiers.org/ncbigene/55770
- genomic end
- 693139
- genomic start
- 485154
- cytogenetic location
- 6p25.3
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.