RALA
Sign in to saveAlso known as RAL, RALA Ras like proto-oncogene A, RAS like proto-oncogene A, HINCONS
Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.
Gene data
RALA- Name
- RAS like proto-oncogene A
- Type
- protein-coding
- Position
- 39,623,445–39,708,124 (+)
- Aliases
- HINCONS, RAL
- Ensembl
- ENSG00000006451
- RefSeq RNA
- NM_005402.4, XM_047420681.1, XM_047420682.1, XM_054358751.1, XM_054358752.1
- RefSeq protein
- NP_005393.2, XP_047276637.1, XP_047276638.1, XP_054214726.1, XP_054214727.1
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RAS like proto-oncogene A
- Symbol
- RALA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:39,623,445-39,708,217
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein RALA PDB 1u8y.png
Show 6 more facts
- HomoloGene ID
- 3942
- exact match
- identifiers.org/ncbigene/5898
- genomic end
- 39708120
- genomic start
- 39623565
- cytogenetic location
- 7p14.1
- Commons category
- Ras-related protein RalA
Sources (4)
via Wikidata · CC0
~3 min read
Article
7 sectionsContents
- Structure
- Function
- Clinical significance
- Interactions
- References
- Further reading
- External links
Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.
== Structure == The Ral isoforms share an 80% overall match in amino acid sequence and 100% match in their effector-binding region. The two isoforms mainly differ in the C-terminal hypervariable region, which contains multiple sites for post-translational modification, leading to diverging subcellular localization and biological function. For example, phosphorylation of Serine 194 on RalA by the kinase Aurora A results in the relocation of RalA to the inner mitochondrial membrane, where RalA helps carry out mitochondrial fission; whereas phosphorylation of Serine 198 on RalB by the kinase PKC results in the relocation of RalB to other internal membranes and activation of its tumorigenic function.