FBXO5

Also known as EMI1, FBX5, Fbxo31, F-box protein 5

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.

In the Vinony graph

Within Vinony's link graph, FBXO5 is referenced by 6 other articles, and connects out to Q180686, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Its subject is documented across 7 Wikipedia language editions.

Gene data

FBXO5

Name: F-box protein 5
Type: protein-coding
Position: 152,970,519–152,983,599 (−)
Aliases: EMI1, FBX5, Fbxo31
Ensembl: ENSG00000112029
RefSeq RNA: NM_001142522.3, NM_012177.5
RefSeq protein: NP_001135994.1, NP_036309.1

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].