CDC20
Sign in to saveAlso known as CDC20A, bA276H19.3, p55CDC, cell division cycle 20
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which
Gene data
CDC20- Name
- cell division cycle 20
- Type
- protein-coding
- Position
- 43,358,928–43,363,207 (+)
- Aliases
- CDC20A, OOMD14, OZEMA14, bA276H19.3, p55CDC
- Ensembl
- ENSG00000117399
- RefSeq RNA
- NM_001255.3
- RefSeq protein
- NP_001246.2
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cell division cycle 20
- Symbol
- CDC20
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:43,358,907-43,363,212
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- CDC20.png
Show 5 more facts
- exact match
- identifiers.org/ncbigene/991
- HomoloGene ID
- 37459
- genomic end
- 43828874
- genomic start
- 43358981
- cytogenetic location
- 1p34.2
via Wikidata · CC0
~7 min read
Article
10 sectionsContents
- Discovery
- Structure
- Interactions
- Regulation
- Cdh1
- Spindle assembly checkpoint
- Cancer
- References
- Further reading
- External links
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.
CDC20 appears to act as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes: nuclear movement prior to anaphase, and chromosome separation.