securin
Sign in to saveSecurin is a protein involved in control of the metaphase-anaphase transition and anaphase onset. Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin, produces an abrupt stimulus that induces highly synchronous chromosome separation in anaphase.
Research
1,049 papers- Structure and Function of the Separase-Securin Complex.Sub-cellular biochemistry · 2021
- Securin acetylation prevents precocious separase activation and premature sister chromatid separation.Current biology : CB · 2024
- Structural biology of the separase-securin complex with crucial roles in chromosome segregation.Current opinion in structural biology · 2018
- Clinical significance of securin expression in solid cancers: A PRISMA-compliant meta-analysis of published studies and bioinformatics analysis based on TCGA dataset.Medicine · 2022
- Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.Nature · 2020
via PubMed
~4 min read
Article
6 sectionsContents
- Securin and Separase
- Role of Securin in the onset of Anaphase
- Basic mechanism
- Network characteristics
- References
- External links
Securin is a protein involved in control of the metaphase-anaphase transition and anaphase onset. Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin, produces an abrupt stimulus that induces highly synchronous chromosome separation in anaphase.
==Securin and Separase== thumb|left|300px|alt=Figure 1|Figure 1: Securin and separase are widely conserved