FKBP10

Also known as FKBP65, OI11, OI6, PPIASE, hFKBP65, BRKS1, FK506 binding protein 10, FKBP prolyl isomerase 10

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.

Gene data

FKBP10

Name: FKBP prolyl isomerase 10
Type: protein-coding
Position: 41,812,079–41,823,221 (+)
Aliases: BRKS, BRKS1, FKBP65, OI11, OI6, PPIASE, TLH1, hFKBP65
Ensembl: ENSG00000141756
RefSeq RNA: NM_021939.4, XM_011525099.4, XM_011525100.3, XM_047436515.1, XM_054316866.1
RefSeq protein: NP_068758.3, XP_011523401.1, XP_011523402.1, XP_047292471.1, XP_054172841.1

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009].

Gene Ontology

Biological process

protein folding

Molecular function

peptidyl-prolyl cis-trans isomerase activity peptidyl-prolyl cis-trans isomerase activity peptidyl-prolyl cis-trans isomerase activity calcium ion binding protein binding FK506 binding FK506 binding

Cellular component

mitochondrial intermembrane space endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum lumen membrane

Pathways

Type I collagen synthesis in the context of Osteogenesis imperfecta

via MyGene.info

Gene · Ensembl

FKBP prolyl isomerase 10

Symbol: FKBP10
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:41,812,079-41,823,221
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 7718
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/60681
chromosome: human chromosome 17
genomic start: 39968932
genomic end: 41823213
cytogenetic location: 17q21.2
genetic association: Bruck syndrome
expressed in: left coronary artery

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
Further reading

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.

Excerpted from Wikipedia’s “FKBP10” article, available under the CC BY-SA 4.0 licence.