Structure via PubChem · Public domain (PubChem)
formononetin
Sign in to saveAlso known as formononetol, 4'-O-methyldaidzein, biochanin B, 7-Hydroxy-3-(4-methoxyphenyl)-4-benzopyrone, 7-Hydroxy-4'-methoxy-Isoflavone, 7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one, 7-Hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one(9CI), 7-Hydroxy-4'-methoxyisoflavone
Formononetin is an O-methylated isoflavone.
Chemical data
- Formula
- C16H12O4
- Molecular weight
- 268.26 g/mol
- IUPAC name
- 7-hydroxy-3-(4-methoxyphenyl)chromen-4-one
- SMILES
- COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O
- InChIKey
- HKQYGTCOTHHOMP-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 55.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- osteoporosis
via ChEMBL · EBI
Research
1,695 papers- Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2/STAT3 signaling pathway.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
- Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
- Formononetin: pharmacological properties and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2025
- Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
- Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2024
via PubMed
Wikidata facts
- Subclass of
- isoflavone
- Mass
- 268.073559
Show 6 more facts
- found in taxon
- Fabaceae
- chemical formula
- C₁₆H₁₂O₄
- canonical SMILES
- COC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O
- subject has role
- phytoestrogen
- has characteristic
- bitterness
- Commons category
- Formononetin
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Natural occurrences
- Pharmacodynamics
- Derivatives
- References
Formononetin is an O-methylated isoflavone.
== Natural occurrences == Formononetin is found in a number of plants and herbs such as red clover. Along with other phytoestrogens, it predominantly occurs in leguminous plants and Fabaceae, particularly in beans, such as green beans, lima beans, soy and many others, as the free aglycone or in form of its glucoside ononin.
Excerpted from Wikipedia’s “formononetin” article, available under the CC BY-SA 4.0 licence.