fructokinase
Sign in to saveAlso known as D-fructokinase, D-fructose(D-mannose)kinase, ATP:D-fructose 6-phosphotransferase, fructokinase (phosphorylating)
Fructokinase (/fruc•to•ki•nase/ [-ki´nas]), also known as D-fructokinase or D-fructose (D-mannose) kinase, is an enzyme () of the liver, intestine, and kidney cortex. Fructokinase is in a family of enzymes called transferases, meaning that this enzyme transfers functional groups; it is also considered a phosphotransferase (or, frequently, a kinase) since it specifically transfers a phosphate group. Fructokinase specifically catalyzes the transfer of a phosphate group from adenosine triphosphate (ATP, the substrate) to fructose as the initial step in its utilization. The main role of fructokina
Key facts
- Enzyme.Name
- Fructokinase
- Enzyme.EC_number
- 2.7.1.4
- Enzyme.CAS_number
- 9030-51-7
- Enzyme.image
- 3lm9.jpg
- Enzyme.width
- 270
- Enzyme.caption
- Fructokinase dimer, Bacillus subtilis
via Wikipedia infobox
Research
6,548 papers- Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.Journal of hepatology · 2018
- Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer.Nature · 2024
- PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis.Cancer research · 2025
- Substantial roles of hexokinase and fructokinase in the effects of sugars on plant physiology and development.Journal of experimental botany · 2014
- The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis.Cell · 2025
via PubMed
~4 min read
Encyclopedic overview
6 sectionsContents
- Role in plants and bacteria
- Role in animals and humans
- Diseases
- See also
- References
- External links
Fructokinase (/fruc•to•ki•nase/ [-ki´nas]), also known as D-fructokinase or D-fructose (D-mannose) kinase, is an enzyme () of the liver, intestine, and kidney cortex. Fructokinase is in a family of enzymes called transferases, meaning that this enzyme transfers functional groups; it is also considered a phosphotransferase (or, frequently, a kinase) since it specifically transfers a phosphate group. Fructokinase specifically catalyzes the transfer of a phosphate group from adenosine triphosphate (ATP, the substrate) to fructose as the initial step in its utilization. The main role of fructokinase is in carbohydrate metabolism, more specifically, sucrose and fructose metabolism. The reaction equation is as follows: ATP + D-fructose → ADP + D-fructose 1-phosphate.
==Role in plants and bacteria==
Excerpted from Wikipedia’s “fructokinase” article, available under the CC BY-SA 4.0 licence.