GGA3

Also known as golgi associated, gamma adaptin ear containing, ARF binding protein 3

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.

Gene data

GGA3

Name: golgi associated, gamma adaptin ear containing, ARF binding protein 3
Type: protein-coding
Position: 75,236,595–75,262,363 (−)
Ensembl: ENSG00000125447
RefSeq RNA: NM_001172703.3, NM_001172704.3, NM_001291641.2, NM_001291642.2, NM_014001.5
RefSeq protein: NP_001166174.1, NP_001166175.1, NP_001278570.1, NP_001278571.1, NP_054720.1

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010].

Pathways

Lysosome - Homo sapiens (human)Signal Transduction Membrane Trafficking Metabolism of proteins Vesicle-mediated transport Signaling by MET TBC/RABGAPs MET receptor recycling Signaling by Receptor Tyrosine Kinases Rab regulation of trafficking

via MyGene.info

Gene · Ensembl

golgi associated, gamma adaptin ear containing, ARF binding protein 3

Symbol: GGA3
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:75,236,595-75,262,363
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein GGA3 PDB 1jpl.png

Show 9 more facts

HomoloGene ID: 121703
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23163
genomic end: 73258444
genomic start: 73232694
chromosome: human chromosome 17
cytogenetic location: 17q25.1
expressed in: fundus
Commons category: ADP-ribosylation factor-binding protein GGA3

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

Interactions
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Further reading

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.

Excerpted from Wikipedia’s “GGA3” article, available under the CC BY-SA 4.0 licence.