ARF1

Name

ARF GTPase 1

Type

protein-coding

Position

228,081,841–228,099,212 (+)

Aliases

PVNH8

Ensembl

ENSG00000143761

RefSeq RNA

NM_001024226.2, NM_001024227.1, NM_001024228.2, NM_001658.4

RefSeq protein

NP_001019397.1, NP_001019398.1, NP_001019399.1, NP_001649.1

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].