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GeneQ17861955· pop 9· linked from 608 articles

CHRM3

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Also known as EGBRS, HM3, PBS, cholinergic receptor muscarinic 3

protein-coding gene in the species Homo sapiens

Gene data

CHRM3

Name: cholinergic receptor muscarinic 3
Type: protein-coding
Position: 239,386,513–239,915,452 (+)
Aliases: EGBRS, HM3, PBS, m3AChR
Ensembl: ENSG00000133019
RefSeq RNA: NM_000740.4, NM_001347716.2, NM_001375978.1, NM_001375979.1, NM_001375980.1
RefSeq protein: NP_000731.1, NP_001334645.1, NP_001362907.1, NP_001362908.1, NP_001362909.1

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].

Gene Ontology

Biological process

regulation of smooth muscle contraction signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway G protein-coupled acetylcholine receptor signaling pathway

Molecular function

phosphatidylinositol-4,5-bisphosphate phospholipase C activity phosphatidylinositol-4,5-bisphosphate phospholipase C activity G protein-coupled receptor activity protein binding G protein-coupled acetylcholine receptor activity G protein-coupled acetylcholine receptor activity G protein-coupled acetylcholine receptor activity G protein-coupled acetylcholine receptor activity

Cellular component

endoplasmic reticulum membrane plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane basal plasma membrane

Pathways

Calcium signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Cholinergic synapse - Homo sapiens (human)Taste transduction - Homo sapiens (human)Regulation of actin cytoskeleton - Homo sapiens (human)Insulin secretion - Homo sapiens (human)Salivary secretion - Homo sapiens (human)Gastric acid secretion - Homo sapiens (human)Pancreatic secretion - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

cholinergic receptor muscarinic 3

Symbol: CHRM3
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:239,386,513-239,915,452
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: 4daj.png

Show 6 more facts

HomoloGene ID: 20191
exact match: identifiers.org/ncbigene/1131
genomic start: 239549865
genomic end: 240078750
cytogenetic location: 1q43
Commons category: Muscarinic acetylcholine receptor M3

Sources (4)

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Categories

Genes on human chromosome 1 Muscarinic acetylcholine receptors