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guanadrel
Sign in to saveAlso known as CL-1388R, Hylorel®, U-28288D, Guanadrelum
Guanadrel is an antihypertensive agent. It is used in the form of its sulfate.
Research
38 papers- Guanadrel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in hypertension.Drugs · 1985
- Comparison of guanadrel and guanethidine.Clinical pharmacology and therapeutics · 1973
- Guanadrel. A new antihypertensive drug.JAMA · 1981
- Cardiovascular profile of the antihypertensive agent, guanadrel.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) · 1972
- Effects of guanadrel on patients with thyrotoxicosis.Archives of internal medicine · 1978
via PubMed
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Encyclopedic overview
3 sectionsContents
- Mechanism of action
- References
- External links
Guanadrel is an antihypertensive agent. It is used in the form of its sulfate.
==Mechanism of action== Guanadrel is a postganglionic adrenergic blocking agent. Uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump; guanadrel slowly displaces norepinephrine from its storage in nerve endings and thereby blocks the release of norepinephrine normally produced by nerve stimulation. The reduction in neurotransmitter release in response to sympathetic nerve stimulation, as a result of catecholamine depletion, leads to reduced arteriolar vasoconstriction, especially the reflex increase in sympathetic tone that occurs with a change in position. Guanadrel is rapidly and well absorbed from gastrointestinal tract.
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