HECW1

Also known as NEDL1, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene. In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.

Gene data

HECW1

Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Type: protein-coding
Position: 43,112,629–43,566,001 (+)
Aliases: NEDL1
Ensembl: ENSG00000002746
RefSeq RNA: NM_001287059.2, NM_015052.5, XM_006715670.4, XM_006715671.4, XM_006715673.4
RefSeq protein: NP_001273988.1, NP_055867.3, XP_006715733.1, XP_006715734.1, XP_006715736.1

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

ubiquitin-dependent protein catabolic process protein ubiquitination regulation of dendrite morphogenesis negative regulation of canonical Wnt signaling pathway

Molecular function

ubiquitin-protein transferase activity protein binding ubiquitin protein ligase activity ubiquitin protein ligase activity ubiquitin protein ligase activity

Cellular component

cytoplasm cytoplasm cytosol cytosol

Pathways

Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Degradation of DVL

via MyGene.info

Gene · Ensembl

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

Symbol: HECW1
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:43,112,629-43,566,001
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 9004
genetic association: obesity
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23072
genomic end: 43605600
genomic start: 43112629
chromosome: human chromosome 7
cytogenetic location: 7p14.1-p13
expressed in: pons

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Encyclopedic overview

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Contents

References
Further reading

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene. In human it has 1606 amino acids (179.5 kDa) and isoelectric point of 5.18.

== References ==

Excerpted from Wikipedia’s “HECW1” article, available under the CC BY-SA 4.0 licence.

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