hexobarbital
Sign in to saveAlso known as 5-(1-cyclohexen-1-yl)-1,5-dimethylbarbituric acid, 5-(1-cyclohexen-1-yl)-1,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione, hexobarbitone, 5-cyclohex-1-enyl-1,5-dimethyl-pyrimidine-2,4,6-trione
Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of effects and short duration of action. Modern barbiturates (such as Thiopental) have largely supplanted the use of hexobarbital as an anesthetic, as they allow for better control of the depth of anesthesia. Hexobarbital is still used in some sci
Research
2,868 papers- [New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 2004
- Polymorphism in stereoselective hydroxylations of mephenytoin and hexobarbital by Japanese liver samples in relation to cytochrome P-450 human-2 (IIC9).Xenobiotica; the fate of foreign compounds in biological systems · 1992
- Disposition of hexobarbital: 15 years of an intriguing model substrate.Drug metabolism reviews · 1988
- Metabolic and psychophysiologic studies of cannabidiol-hexobarbital interaction.Clinical pharmacology and therapeutics · 1980
- [True hexobarbital tolerance].Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie · 1965
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Wikidata facts
- Mass
- 236.116092
Show 4 more facts
- chemical formula
- C₁₂H₁₆N₂O₃
- canonical SMILES
- CC1(C(=O)NC(=O)N(C1=O)C)C2=CCCCC2
- defined daily dose
- 0.25
- Commons category
- Hexobarbital
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Article
13 sectionsContents
- History
- Application in research
- Synthesis
- Reactivity
- Toxicity
- Mechanism of actions
- Metabolism
- Health effects in man
- Excretion
- Symptoms
- Effects on animals
- In popular culture
- References
Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of effects and short duration of action. Modern barbiturates (such as Thiopental) have largely supplanted the use of hexobarbital as an anesthetic, as they allow for better control of the depth of anesthesia. Hexobarbital is still used in some scientific research.
== History == The chemical class of barbiturates are one of the oldest sedative-hypnotic agents known, dating back from the introduction of barbital in the early 20th century. In Hungary, hexobarbital (and other barbiturates) were regularly used as drugs by pregnant women attempting suicide. Hexobarbital was long thought to have potentially teratogenic and fetotoxic effects. The FDA has classified them as Pregnancy Category D or C. Some research however, indicate that ingestion of Hexobarbital might cause congenital abnormalities.