HMG20B
Sign in to saveAlso known as BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.
Gene data
HMG20B- Name
- high mobility group 20B
- Type
- protein-coding
- Position
- 3,572,692–3,579,088 (+)
- Aliases
- BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857
- Ensembl
- ENSG00000064961
- RefSeq RNA
- NM_006339.3, XM_017026144.2, XM_054319533.1
- RefSeq protein
- NP_006330.2, XP_016881633.1, XP_054175508.1
Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
high mobility group 20B
- Symbol
- HMG20B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:3,572,692-3,579,088
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein HMG20B PDB 2crj.png
Show 7 more facts
- HomoloGene ID
- 74949
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10362
- genomic end
- 3579086
- genomic start
- 3572775
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.
HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins.
Excerpted from Wikipedia’s “HMG20B” article, available under the CC BY-SA 4.0 licence.