HSD11B2

Name

hydroxysteroid 11-beta dehydrogenase 2

Type

protein-coding

Position

67,430,652–67,437,553 (+)

Aliases

AME, AME1, HSD11K, HSD2, SDR9C3

Ensembl

ENSG00000176387

RefSeq RNA

NM_000196.4, XM_047434048.1

RefSeq protein

NP_000187.3, XP_047290004.1

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010].

via MyGene.info

Gene · Ensembl

hydroxysteroid 11-beta dehydrogenase 2

Symbol

HSD11B2

Biotype

Protein coding

Organism

Homo sapiens

Location

16:67,430,652-67,437,553

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

via Wikidata · CC0