hypromellose
Also known as hydroxypropyl methylcellulose, HPMC
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
Chemical data
- Formula
- C56H108O30
- Molecular weight
- 1261.4 g/mol
- IUPAC name
- (2R,3R,4S,5R,6R)-2,3,4-trimethoxy-6-(methoxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[(2R,3R,4S,5R,6S)-3,4,5-tris(2-hydroxypropoxy)-6-[(2R,3R,4S,5R,6R)-4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
- SMILES
- CC(COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O.COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OC)OC)OC)COC)OC)OC)OC
- InChIKey
- PUSNGFYSTWMJSK-GSZQVNRLSA-N
- Polar surface area
- 365 Ų
- H-bond donors
- 8
- H-bond acceptors
- 30
- Formal charge
- 0
via PubChem
Article
15 sectionsContents
- Chemistry
- Uses
- Use in whole grain breads
- Use in construction materials
- Ophthalmic applications
- Excipient/tableting ingredient
- Test methods
- Viscosity test methods
- Degree of substitution
- Molar substitution
- Moisture
- Ash Content
- See also
- References
- External links
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Its Codex Alimentarius code (E number) is E464.