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hypromellose
Sign in to saveAlso known as hydroxypropyl methylcellulose, HPMC
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
Chemical data
- Formula
- C56H108O30
- Molecular weight
- 1261.4 g/mol
- IUPAC name
- (2R,3R,4S,5R,6R)-2,3,4-trimethoxy-6-(methoxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[(2R,3R,4S,5R,6S)-3,4,5-tris(2-hydroxypropoxy)-6-[(2R,3R,4S,5R,6R)-4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
- SMILES
- CC(COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O.COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OC)OC)OC)COC)OC)OC)OC
- InChIKey
- PUSNGFYSTWMJSK-GSZQVNRLSA-N
- Polar surface area
- 365 Ų
- H-bond donors
- 8
- H-bond acceptors
- 30
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- polysaccharide
- Has part
- hydrogen
- Mass
- 748.3728797000001
- Has use
- excipient
Show 3 more facts
- chemical formula
- C₅₆H₁₀₈O₃₀
- canonical SMILES
- CC(COCC1C(C(C(C(O1)OC)OCC(C)O)OCC(C)O)OC2C(C(C(C(O2)COC)OC3C(C(C(C(O3)CO)OC)O)O)OC)OC)O
- Commons category
- Hypromellose
Sources (1)
via Wikidata · CC0
~7 min read
Encyclopedic overview
15 sectionsContents
- Chemistry
- Uses
- Use in whole grain breads
- Use in construction materials
- Ophthalmic applications
- Excipient/tableting ingredient
- Test methods
- Viscosity test methods
- Degree of substitution
- Molar substitution
- Moisture
- Ash Content
- See also
- References
- External links
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin. Its Codex Alimentarius code (E number) is E464.
Excerpted from Wikipedia’s “hypromellose” article, available under the CC BY-SA 4.0 licence.