iclazepam

Iclazepam (Clazepam) is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as chlordiazepoxide.

In the Vinony graph

Within Vinony's link graph, iclazepam is referenced by 540 other articles, and connects out to benzodiazepine drug, alphenal and zapizolam.

It is catalogued under topics including Benzodiazepines, Chemical pages without DrugBank identifier and Chloroarenes.

Its subject is documented across 7 Wikipedia language editions.

Chemical data

Formula: C21H21ClN2O2
Molecular weight: 368.9 g/mol
IUPAC name: 7-chloro-1-[2-(cyclopropylmethoxy)ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
SMILES: C1CC1COCCN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4
InChIKey: PLRHQQPBNXIHAZ-UHFFFAOYSA-N
XLogP: 3.4
Polar surface area: 41.9 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 368.129

Show 2 more facts

chemical formula: C₂₁H₂₁ClN₂O₂
canonical SMILES: C1CC1COCCN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

See also
References

Iclazepam is a derivative of nordazepam substituted with a cyclopropylmethoxyethyl group on the N1 nitrogen. Once in the body, iclazepam is quickly metabolised to nordazepam and its N-(2-hydroxyethyl) derivative, which are thought to be mainly responsible for its effects.

Excerpted from Wikipedia’s “iclazepam” article, available under the CC BY-SA 4.0 licence.