ifenprodil
Sign in to saveAlso known as (±)-ifenprodil, RC 61-91
Ifenprodil, sold under the brand names Cerocral, Dilvax, and Vadilex, is a cerebral vasodilator that has been marketed in some countries, including in Japan, Hong Kong, and France. It is currently under development for treatment of a variety of additional indications.
Key facts
- Drug.KEGG
- D08064
- Drug.ChEBI
- 93829
- Drug.ChEMBL
- 305187
- Drug.Verifiedfields
- verified
- Drug.verifiedrevid
- 461742484
- Drug.image
- Ifenprodil structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.tradename
- Cerocral, Dilvax, Vadilex
- Drug.class
- Cerebral vasodilators; NMDA receptor antagonists
- Drug.ATC_prefix
- C04
- Drug.ATC_suffix
- AX28
- Drug.CAS_number
- 23210-56-2
- Drug.PubChem
- 3689
- Drug.IUPHAR_ligand
- 5472
- Drug.ChemSpiderID
- 3561
- Drug.UNII
- R8OE3P6O5S
- Drug.synonyms
- NP-120; NP 120; NP120; RC 61-91
via Wikipedia infobox
Research
1,222 papers- Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action.Current drug targets · 2001
- The glutamate receptor antagonist ifenprodil inhibits hepatitis E virus infection.Antimicrobial agents and chemotherapy · 2024
- Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.Journal of medicinal chemistry · 2021
- Ifenprodil for the treatment of methamphetamine use disorder: An exploratory, randomized, double-blind, placebo-controlled trial.Neuropsychopharmacology reports · 2022
- Ifenprodil tartrate treatment of adolescents with post-traumatic stress disorder: A double-blind, placebo-controlled trial.Psychiatry research · 2022
via PubMed
~1 min read
Encyclopedic overview
3 sectionsContents
- Research
- See also
- References
Ifenprodil, sold under the brand names Cerocral, Dilvax, and Vadilex, is a cerebral vasodilator that has been marketed in some countries, including in Japan, Hong Kong, and France. It is currently under development for treatment of a variety of additional indications.
Ifenprodil has multiple known pharmacological actions. It is an inhibitor of the NMDA receptor, specifically of NMDA receptors containing GluN1 and GluN2B subunits, the "ifenprodil binding site". Additionally, ifenprodil inhibits GIRK channels and interacts with α1-adrenergic, serotonin, and sigma receptors.
Excerpted from Wikipedia’s “ifenprodil” article, available under the CC BY-SA 4.0 licence.
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