IGF2BP2

Also known as IMP-2, IMP2, VICKZ2, insulin like growth factor 2 mRNA binding protein 2

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.

Gene data

IGF2BP2

Name: insulin like growth factor 2 mRNA binding protein 2
Type: protein-coding
Position: 185,643,130–185,825,061 (−)
Aliases: IMP-2, IMP2, VICKZ2
Ensembl: ENSG00000073792
RefSeq RNA: NM_001007225.3, NM_001291869.3, NM_001291872.3, NM_001291873.3, NM_001291874.3
RefSeq protein: NP_001007226.1, NP_001278798.1, NP_001278801.1, NP_001278802.1, NP_001278803.1

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016].

Gene Ontology

Biological process

regulation of cytokine production regulation of cytokine production

Article

3 sections

Contents

See also
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Further reading

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.