IGF2BP1

Also known as CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1, insulin like growth factor 2 mRNA binding protein 1

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.

Gene data

IGF2BP1

Name: insulin like growth factor 2 mRNA binding protein 1
Type: protein-coding
Position: 48,997,225–49,056,148 (+)
Aliases: CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
Ensembl: ENSG00000159217
RefSeq RNA: NM_001160423.2, NM_006546.4, XM_005256955.4, XM_011524201.3, XM_017024022.2
RefSeq protein: NP_001153895.1, NP_006537.3, XP_005257012.2, XP_011522503.1, XP_016879511.1

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].

Pathways

MicroRNAs in cancer - Homo sapiens (human)Signal Transduction Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MAPK family signaling cascades MAPK6/MAPK4 signaling Metabolism of RNA Brain-derived neurotrophic factor (BDNF) signaling pathway eIF5A regulation in response to inhibition of the nuclear export system

via MyGene.info

Gene · Ensembl

insulin like growth factor 2 mRNA binding protein 1

Symbol: IGF2BP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:48,997,225-49,056,148
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 4772
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10642
genomic end: 49056145
genomic start: 48997385
chromosome: human chromosome 17
cytogenetic location: 17q21.32
expressed in: retinal pigment epithelium

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via Wikidata · CC0

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Encyclopedic overview

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Further reading

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.

Excerpted from Wikipedia’s “IGF2BP1” article, available under the CC BY-SA 4.0 licence.