isochromosome
Sign in to saveAlso known as isochromosomes
thumb|Isochromosome in which the arms are mirror copies of each other.
Research
1,854 papers- Isochromosome X in Myelodysplastic Syndrome.Acta haematologica · 2016
- Mosaic isochromosome 20q at amniocentesis: Prenatal diagnosis, genetic counseling and literature review.Taiwanese journal of obstetrics & gynecology · 2019
- SETD2 safeguards the genome against isochromosome formation.Proceedings of the National Academy of Sciences of the United States of America · 2023
- Does isochromosome 7q mandate bone marrow transplant in children with Shwachman-Diamond syndrome?British journal of haematology · 2002
- Isochromosome 12p Formation Regulates Vitamin D Metabolism in Testicular Cancer.Nutrients · 2023
via PubMed
~6 min read
Encyclopedic overview
8 sectionsContents
- Nomenclature
- Mechanism
- Centromere misdivision
- U-type strand exchange
- Consequences
- Turner syndrome
- Neoplasia
- References
thumb|Isochromosome in which the arms are mirror copies of each other.
An isochromosome is an unbalanced structural abnormality in which the arms of the chromosome are mirror images of each other. The chromosome consists of two copies of either the long (q) arm or the short (p) arm because isochromosome formation is equivalent to a simultaneous duplication and deletion of genetic material. Consequently, there is partial trisomy of the genes present in the isochromosome and partial monosomy of the genes in the lost arm.
Excerpted from Wikipedia’s “isochromosome” article, available under the CC BY-SA 4.0 licence.