isoliquiritigenin
Also known as (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone, trans-2',4,4'-trihydroxychalcone, (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one, 2',4,4'-Trihydroxychalcone, ILTG
Isoliquiritigenin is a chalcone found in the roots of several Glycyrrhiza species, such as liquorice, studied for its activity as a tyrosinase inhibitor, NMDA receptor antagonist, GABA modulator, and its potential antineoplastic and geroprotective effects.
Research
1,087 papers- Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.Redox biology · 2024
- Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells.Chinese medical journal · 2023
- Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases.Journal of ethnopharmacology · 2024
- Isoliquiritigenin alleviates myocardial ischemia-reperfusion injury by regulating the Nrf2/HO-1/SLC7a11/GPX4 axis in mice.Free radical biology & medicine · 2024
- Isoliquiritigenin (ISL) and its Formulations: Potential Antitumor Agents.Current medicinal chemistry · 2019
via PubMed
~2 min read
Article
5 sectionsContents
- Occurrence
- Pharmacological properties
- Pharmakokinetics
- Mechanism of action
- References
Isoliquiritigenin is a chalcone found in the roots of several Glycyrrhiza species, such as liquorice, studied for its activity as a tyrosinase inhibitor, NMDA receptor antagonist, GABA modulator, and its potential antineoplastic and geroprotective effects.
== Occurrence == left|thumb|Liquorice roots Isoliquiritigenin occurs in some species of the genus Glycyrrhiza, including Glycyrrhiza glabra (licorice).