Isostere
Sign in to saveClassical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available, but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere. This is frequently used in drug design: the bioisostere will still be recognized and accepted by the body, but its functions there will be altered as compared to the parent molecule.
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Within Vinony's link graph, Isostere is referenced by 18 other articles, and connects out to molecule, International Standard Book Number and ion.
Vinony files it under Drug discovery and Theoretical chemistry.
Its subject is documented across 10 Wikipedia language editions.
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Encyclopedic overview
2 sectionsContents
- History and additional definitions
- References
Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available, but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere. This is frequently used in drug design: the bioisostere will still be recognized and accepted by the body, but its functions there will be altered as compared to the parent molecule.
==History and additional definitions== Non-classical isosteres do not obey the above classifications, but they still produce similar biological effects in vivo. Non-classical isosteres may be made up of similar atoms, but their structures do not follow an easily definable set of rules.
Excerpted from Wikipedia’s “Isostere” article, available under the CC BY-SA 4.0 licence.