isozyme
Sign in to saveAlso known as isoenzymes, multiple forms of enzymes, izoenzymy, isoenzyme, isozymes
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes or isoforms) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. different KM values), or are regulated differently. They permit the fine-tuning of metabolism to meet the particular needs of a given tissue or developmental stage.
Research
101,232 papers- Protein kinase C (PKC) isozyme-specific substrates and their design.Biotechnology advances · 2012
- Clinical and biological significance of an isozyme tumor marker--PLAP.Clinical biochemistry · 1987
- [Isozyme analysis by enzyme immunoassay (EIA)--clinical significance and future prospect].Nihon rinsho. Japanese journal of clinical medicine · 1995
- [Lactate dehydrogenase (LDH)].Nihon rinsho. Japanese journal of clinical medicine · 1995
- Protein kinase C isozyme selective peptides--a current view of what they tell us about location and function of isozymes in the heart.Current pharmaceutical design · 2005
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7 sectionsContents
- Introduction
- Examples
- Distinguishing isozymes
- Isozymes and allozymes as molecular markers
- Other major examples
- References
- External links
In biochemistry, isozymes (also known as isoenzymes or more generally as multiple forms of enzymes or isoforms) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. Isozymes usually have different kinetic parameters (e.g. different KM values), or are regulated differently. They permit the fine-tuning of metabolism to meet the particular needs of a given tissue or developmental stage.
In many cases, isozymes are encoded by homologous genes that have diverged over time. Strictly speaking, enzymes with different amino acid sequences that catalyse the same reaction are isozymes if encoded by different genes, or allozymes if encoded by different alleles of the same gene; the two terms are often used interchangeably.