PDK4
Sign in to saveAlso known as pyruvate dehydrogenase kinase 4
Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. It codes for an isozyme of pyruvate dehydrogenase kinase.
Gene data
PDK4- Name
- pyruvate dehydrogenase kinase 4
- Type
- protein-coding
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
pyruvate dehydrogenase kinase 4
- Symbol
- PDK4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:95,583,497-95,597,638
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PDK4 PDB 2E0A.png
Show 5 more facts
- HomoloGene ID
- 129720
- exact match
- identifiers.org/ncbigene/5166
- genomic end
- 95596516
- genomic start
- 95212811
- cytogenetic location
- 7q21.3
via Wikidata · CC0
~6 min read
Article
8 sectionsContents
- Structure
- Function
- Regulation
- Clinical significance
- Cancer
- Interactive pathway map
- References
- Further reading
Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. It codes for an isozyme of pyruvate dehydrogenase kinase.
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, reducing the conversion of pyruvate, which is produced from the oxidation of glucose and amino acids, to acetyl-CoA and contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. PDK4 is increased in hibernation and helps to decrease metabolism and conserve glucose by decreasing its conversion to acetyl-CoA, which enters the citric acid cycle and is converted to ATP.