Also known as involucrin
Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.
Gene data
IVL- Name
- involucrin
- Type
- protein-coding
- Position
- 152,908,539–152,911,886 (+)
- Ensembl
- ENSG00000163207
- RefSeq RNA
- NM_005547.4
- RefSeq protein
- NP_005538.2
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
involucrin
- Symbol
- IVL
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:152,908,539-152,911,886
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- IVL protein.png
Show 8 more facts
- HomoloGene ID
- 136793
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3713
- genomic end
- 152884362
- genomic start
- 152908546
- chromosome
- human chromosome 1
- cytogenetic location
- 1q21.3
- expressed in
- Human penis
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Gene
- Function
- Clinical significance
- Structure
- References
- Further reading
Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.
== Gene ==
Excerpted from Wikipedia’s “IVL” article, available under the CC BY-SA 4.0 licence.