TCHH

Also known as THH, THL, TRHY, trichohyalin, UHS3

Trichohyalin is a protein that in mammals is encoded by the TCHH gene.

Gene data

TCHH

Name: trichohyalin
Type: protein-coding
Position: 152,106,317–152,115,444 (−)
Aliases: THH, THL, TRHY, UHS3
Ensembl: ENSG00000159450
RefSeq RNA: NM_007113.4
RefSeq protein: NP_009044.2

The protein encoded by this gene forms crosslinked complexes with itself and keratin intermediate filaments to provide mechanical strength to the hair follicle inner root sheath. The encoded protein also is important for structural integrity of the filiform papillae of the tongue. Defects in this gene are a cause of uncombable hair syndrome. [provided by RefSeq, Feb 2017].

Gene Ontology

Biological process

intermediate filament organization intermediate filament organization

Molecular function

calcium ion binding calcium ion binding protein-macromolecule adaptor activity transition metal ion binding

Cellular component

cornified envelope cytosol cytoskeleton

Pathways

Developmental Biology Keratinization Formation of the cornified envelope

via MyGene.info

Gene · Ensembl

trichohyalin

Symbol: TCHH
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:152,106,317-152,115,444
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 4 more facts

exact match: identifiers.org/ncbigene/7062
genomic start: 152078793
genomic end: 152115444
cytogenetic location: 1q21.3

Sources (4)

via Wikidata · CC0

~4 min read

Article

10 sections

Contents

Discovery
Gene location
Protein localisation
Function
Structure
Post-translational modifications
Interactions
Clinical significance
References
Further reading

Trichohyalin is a protein that in mammals is encoded by the TCHH gene.

== Discovery == In 1903 the name trichohyalin was assigned to the granules of the inner root sheath (IRS) of hair follicles discovered by Hans Vörner. In 1986 the name was reassigned to a protein isolated from sheep wool follicles.