kallidin
Sign in to saveKallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Removal of the N-terminal lysine by Factor XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule.
Research
777 papers- Hypotensive peptides: bradykinin, kallidin, and eledoisin.Advances in pharmacology · 1966
- [Biochemistry of bradykinin and kallidin].Seikagaku. The Journal of Japanese Biochemical Society · 1967
- Bradykinin, kallidin, and their synthetic analogues.Experientia · 1964
- Receptors for bradykinin and kallidin.Canadian journal of physiology and pharmacology · 1979
- [Kallidin and bradykinin].Archives internationales de pharmacodynamie et de therapie · 1953
via PubMed
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Encyclopedic overview
6 sectionsContents
- Formation of Kinins
- Effects of Kinins and Its Role in Disease
- Chemical Mechanisms
- Clarification
- See also
- References
Kallidin belongs to the family kinins, which are the peptide hormones. Kallidin is a decapeptide whose sequence is H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH. Removal of the N-terminal lysine by Factor XII, or to a leser extent aminopeptidase yields the potently bioactive bradykinin molecule.
== Formation of Kinins == In the early 1940s, researcher Eugen Werle worked extensively with his colleague Fritz Fiedler to study enzymes like kallikrein and their biological activation and inhibition behavior at different pH. Their research defined the properties and chemical actions of kallikrein, an enzyme in the kinin-kallikrein system that is connected to the body's cardiovascular, renal and inflammatory systems.
Excerpted from Wikipedia’s “kallidin” article, available under the CC BY-SA 4.0 licence.