UTS2
Sign in to saveAlso known as PRO1068, U-II, UCN2, UII, urotensin 2
Urotensin-II (U-II) is a peptide ligand that is the strongest known vasoconstrictor. Because of the involvement of the UII system in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it represents a promising target for the development of new drugs.
Gene data
UTS2- Name
- urotensin 2
- Type
- protein-coding
- Aliases
- PRO1068, U-II, UCN2, UII
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
urotensin 2
- Symbol
- UTS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:7,843,008-7,853,512
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4939
- exact match
- identifiers.org/ncbigene/10911
- genomic end
- 7913572
- genomic start
- 7903143
- cytogenetic location
- 1p36.23
via Wikidata · CC0
~5 min read
Article
9 sectionsContents
- Discovery
- Structure
- Receptor
- Tissue localization
- Function
- Central nervous system
- Peripheral tissue effects
- References
- Further reading
Urotensin-II (U-II) is a peptide ligand that is the strongest known vasoconstrictor. Because of the involvement of the UII system in multiple biological systems such as the cardiovascular, nervous, endocrine, and renal, it represents a promising target for the development of new drugs.
In humans, Urotensin-2 is encoded by the UTS2 gene.