karyopherins
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Karyopherins are transport proteins involved in the nuclear transport of moving molecules between the cytoplasm and the nucleus of a eukaryotic cell. (The inside of the nucleus is called the karyoplasm (or nucleoplasm). Generally, karyopherin-mediated transport occurs through nuclear pores which act as gateways into and out of the nucleus. Macromolecular proteins require karyopherins to traverse the nuclear pore.
Research
4,714 papers- Karyopherins in cancer.Current opinion in cell biology · 2018
- Karyopherins and nuclear import.Current opinion in structural biology · 2001
- Karyopherins: from nuclear-transport mediators to nuclear-function regulators.Trends in cell biology · 2004
- Karyopherin-mediated nucleocytoplasmic transport.Nature reviews. Molecular cell biology · 2022
- Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.Cell · 2018
via PubMed
~2 min read
Article
5 sectionsContents
- Importin beta
- Human genes in the karyopherin family
- Additional images
- References
- External links
Karyopherins are transport proteins involved in the nuclear transport of moving molecules between the cytoplasm and the nucleus of a eukaryotic cell. (The inside of the nucleus is called the karyoplasm (or nucleoplasm). Generally, karyopherin-mediated transport occurs through nuclear pores which act as gateways into and out of the nucleus. Macromolecular proteins require karyopherins to traverse the nuclear pore.
Karyopherins can act as importins helping proteins to enter the nucleus, or as exportins helping proteins to exit the nucleus. They belong to the nuclear pore complex family in the transporter classification database (TCDB). Energy for transport is derived from the Ran gradient.