XPO1

Also known as CRM1, emb, exp1, exportin 1, CRM-1

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

Gene data

XPO1

Name: exportin 1
Type: protein-coding
Position: 61,476,032–61,538,753 (−)
Aliases: CRM-1, CRM1, emb, exp1
Ensembl: ENSG00000082898
RefSeq RNA: NM_001410799.1, NM_003400.4, XM_005264544.3, XM_005264546.3, XM_006712094.4
RefSeq protein: NP_001397728.1, NP_003391.1, XP_005264601.1, XP_005264603.1, XP_006712157.1

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015].

Pathways

Ribosome biogenesis in eukaryotes - Homo sapiens (human)RNA transport - Homo sapiens (human)Influenza A - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Developmental Biology Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Signal Transduction HIV Life Cycle

via MyGene.info

Gene · Ensembl

exportin 1

Symbol: XPO1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:61,476,032-61,538,753
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: XPO1 prot.png

Show 9 more facts

HomoloGene ID: 2554
exact match: identifiers.org/ncbigene/7514
genomic start: 61476032
found in taxon: Homo sapiens
genomic end: 61538741
chromosome: human chromosome 2
cytogenetic location: 2p15
genetic association: chronic lymphocytic leukemia
Commons category: Exportin-1 (Xpo1, Crm1)

Sources (5)

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Encyclopedic overview

8 sections

Contents

History
Function
Medical relevance
Interactions
See also
References
Further reading
External links

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.

== History == XPO1 (CRM1) originally was identified in the fission yeast Schizosaccharomyces pombe in a genetic screen, and investigators determined that it was involved in control of the chromosome structure. It was later shown to be the nuclear transport receptor for cargos with leucine-rich nuclear export signals (NES). The structural details of the interaction of XPO1 with its cargos were revealed two decades after the gene was identified.

Excerpted from Wikipedia’s “XPO1” article, available under the CC BY-SA 4.0 licence.