DAXX

Also known as BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40

protein-coding gene in the species Homo sapiens

Gene data

DAXX

Name: death domain associated protein
Type: protein-coding
Position: 33,318,558–33,323,259 (−)
Aliases: BING2, DAP6, EAP1
Ensembl: ENSG00000206279
RefSeq RNA: NM_001141969.2, NM_001141970.2, NM_001254717.2, NM_001350.5, XM_005248860.4
RefSeq protein: NP_001135441.1, NP_001135442.1, NP_001241646.1, NP_001341.1, XP_005248917.1

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008].