KEAP1

Name

kelch like ECH associated protein 1

Type

protein-coding

Position

10,486,119–10,503,558 (−)

Aliases

INrf2, KLHL19

Ensembl

ENSG00000079999

RefSeq RNA

NM_012289.4, NM_203500.2

RefSeq protein

NP_036421.2, NP_987096.1

This gene encodes a cytoplasmic regulatory protein that plays a role in the cellular response to oxidative and electrophilic stress. The encoded protein regulates NRF2, a transcription factor that controls the expression of antioxidant and cytoprotective genes. Under non-stress conditions, KEAP1 binds NRF2 and promotes its ubiquitination and proteasomal degradation, thereby maintaining low NRF2 levels. During oxidative or electrophilic stress, conformational changes in KEAP1 impair its ability to promote NRF2 degradation, allowing NRF2 to activate genes that protect cells from oxidative damage and toxic insults. [provided by RefSeq, Mar 2026].