Structure via PubChem · Public domain (PubChem)
lactitol
Sign in to saveAlso known as D-lactitol
Lactitol is a disaccharide sugar alcohol produced from lactose. It is used as a replacement bulk sweetener for low calorie foods with 30–40% of the sweetness of sucrose. It is also used medically as a laxative.
Key facts
- Drug.pregnancy_US
- N
- Drug.image
- lactitol.svg
- Drug.image_class
- skin-invert-image
- Drug.JAN
- Lactitol Hydrate
- Drug.tradename
- Importal, Pizensy, Lacty
- Drug.DailyMedID
- Lactitol
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AD12
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 585-86-4
- Drug.PubChem
- 157355
- Drug.DrugBank
- DB12942
- Drug.ChemSpiderID
- 138481
- Drug.UNII
- L2B0WJF7ZY
- Drug.KEGG
- D08266
- Drug.ChEBI
- 75323
- Drug.ChEMBL
- 1661
via Wikipedia infobox
Chemical data
- Formula
- C12H24O11
- Molecular weight
- 344.31 g/mol
- IUPAC name
- (2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
- SMILES
- C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O)O)O)O
- InChIKey
- VQHSOMBJVWLPSR-JVCRWLNRSA-N
- XLogP
- -5.2
- Polar surface area
- 201 Ų
- H-bond donors
- 9
- H-bond acceptors
- 11
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2020
- Admin. routes
- oral
- Indications
- Constipation, constipation disorder
via ChEMBL · EBI
Research
370 papers- Lactitol.Lancet (London, England) · 1987
- Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis.Digestive diseases and sciences · 1993
- Sugar alcohols derived from lactose: lactitol, galactitol, and sorbitol.Applied microbiology and biotechnology · 2020
- Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis.Clinical and experimental gastroenterology · 2014
- Lactitol or lactulose in the treatment of chronic constipation: result of a systematic.Journal of the Indian Medical Association · 2010
via PubMed
Wikidata facts
- Subclass of
- disaccharide
- Has part
- hydrogen
- Mass
- 344.131862
- Has use
- sweetener
Show 6 more facts
- chemical formula
- C₁₂H₂₄O₁₁
- Commons category
- Lactitol
- canonical SMILES
- C(C1C(C(C(C(O1)OC(C(CO)O)C(C(CO)O)O)O)O)O)O
- isomeric SMILES
- C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O)O)O)O
- World Health Organisation international non-proprietary name
- lactitol
- subject has role
- cathartic
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Production
- Applications
- Medical
- Safety and health
- History
- References
- External links
Lactitol is a disaccharide sugar alcohol produced from lactose. It is used as a replacement bulk sweetener for low calorie foods with 30–40% of the sweetness of sucrose. It is also used medically as a laxative.
==Production== Lactitol is produced by hydrogenation of lactose using Raney nickel catalyst. The product can be obtained as an anhydrous, monohydrate, or dihydrate. Two manufacturers, Danisco and Purac Biochem, produce about 10,000 tons/y.
Excerpted from Wikipedia’s “lactitol” article, available under the CC BY-SA 4.0 licence.