Structure via PubChem · Public domain (PubChem)
lidoflazine
Sign in to saveLidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964. In 2025 Lidoflazine has also been reported to interact with tubulin and inhibit its polymerization.
Chemical data
- Formula
- C30H35F2N3O
- Molecular weight
- 491.6 g/mol
- IUPAC name
- 2-[4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide
- SMILES
- CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
- InChIKey
- ZBIAKUMOEKILTF-UHFFFAOYSA-N
- XLogP
- 6
- Polar surface area
- 35.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 491.275
Show 3 more facts
- chemical formula
- C₃₀H₃₅F₂N₃O
- canonical SMILES
- CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
- subject has role
- calcium channel blocker
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Physical properties
- Solubility at room temperature
- References
- Further reading
Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964. In 2025 Lidoflazine has also been reported to interact with tubulin and inhibit its polymerization.
==Physical properties== ===Solubility at room temperature===
Excerpted from Wikipedia’s “lidoflazine” article, available under the CC BY-SA 4.0 licence.