lifitegrast
Sign in to saveAlso known as compound 1g [PMID: 24900456], SAR 1118, SAR-1118, SAR-1118-023, Xiidra®, SAR1118
Lifitegrast, sold under the brand name Xiidra (), is a medication for the treatment of signs and symptoms of dry eye, a syndrome called keratoconjunctivitis sicca. Lifitegrast reduces inflammation by inhibiting inflammatory cell binding. It is often used as an alternative to ciclosporin (Ikervis, Restasis, Vevye, Verkazia or Cequa) for dry eye treatment including meibomian gland dysfunction and inflammatory dry eye.
Key facts
- Drug.ChEBI
- 133023
- Drug.ChEMBL
- 2048028
- Drug.image
- Lifitegrast skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Xiidra
- Drug.MedlinePlus
- a616039
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- Eye drops
- Drug.ATC_prefix
- S01
- Drug.ATC_suffix
- XA25
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 1025967-78-5
- Drug.PubChem
- 11965427
- Drug.DrugBank
- DB11611
- Drug.ChemSpiderID
- 10139520
- Drug.UNII
- 038E5L962W
via Wikipedia infobox
Research
165 papersvia PubMed
Wikidata facts
- Mass
- 614.068127
Show 4 more facts
- chemical formula
- C₂₉H₂₄Cl₂N₂O₇S
- canonical SMILES
- CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl
- isomeric SMILES
- CS(=O)(=O)C1=CC(C[C@H](NC(=O)C2=C(Cl)C3=C(CN(CC3)C(=O)C4=CC5=C(C=CO5)C=C4)C=C2Cl)C(O)=O)=CC=C1
- Commons category
- Lifitegrast
Sources (2)
via Wikidata · CC0
~4 min read
Article
5 sectionsContents
- Adverse effects
- Pharmacology
- Mechanism of action
- History
- References
{{Infobox drug | image = Lifitegrast skeletal.svg | image_class = skin-invert-image | alt = | caption =
| pronounce = | tradename = Xiidra | Drugs.com = | MedlinePlus = a616039 | pregnancy_AU = B1 | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = Eye drops | ATCvet = | ATC_prefix = S01 | ATC_suffix = XA25