liver failure

Also known as reduced liver function, hepatic insufficiency, liver insufficiency

inability of the liver to perform its normal functions

Key facts

Other names: Hepatic insufficiency, liver dysfunction
Specialty: Gastroenterology , hepatology
Symptoms: abdominal inflammation, fluid retention , hyperglycemia , nausea , vomiting , jaundice , acute or chronic fatigue , hyponatremia , hypokalemia , respiratory alkalosis , metabolic acidosis , bilirubinuria , glycosuria , pruritus
Risk factors: Excessive consumption of alcohol , fatty foods; obesity; Type 2 Diabetes ; anabolic steroids ; sharing or reusing syringes

via Wikipedia infobox

Research

96,402 papers

Neonatal acute liver failure.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2016
Pathophysiology of Acute Liver Failure.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2020
Acute liver failure.The New England journal of medicine · 2013
Acute Liver Failure in Children.Critical care nursing clinics of North America · 2022
Pediatric Acute Liver Failure.Critical care clinics · 2022

via PubMed

Clinical Trials

1,131 registered

NATERMINATED
Re-treatment of HCV Following DAA FailureSanjay Gandhi Postgraduate Institute of Medical Sciences · NCT03483987
PHASE3COMPLETED
A 6-month Efficacy, Safety, and Tolerability Study of Rifaximin In Preventing Hepatic EncephalopathyBausch Health Americas, Inc. · NCT00298038
PHASE2COMPLETED
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron OverloadNovartis Pharmaceuticals · NCT00600938
PHASE4RECRUITING
Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic HyponatremiaUniversity Hospital, Basel, Switzerland · NCT04447911
PHASE1/PHASE2NOT_YET_RECRUITING
EDN Combined With TACE/HAIC and Second-Line Immune-Targeted Treatment Versus TACE/HAIC Alone in Locally Advanced HCC With Portal Vein Tumor Thrombosis After First-Line Therapy Failure: A Prospective, Multicenter, Randomized Controlled TrialZhongda Hospital · NCT07187284
COMPLETED
Long-Term Study on Safety and Immunogenicity of HEPLISAV™ and Engerix-B® in Adults With Chronic Kidney DiseaseDynavax Technologies Corporation · NCT01282762

via ClinicalTrials.gov

Wikidata facts

Image: Depiction of a liver failure patient.png

Show 2 more facts

exact match: purl.obolibrary.org/obo/HP_0001399
Commons category: Liver failure

Sources (4)

via Wikidata · CC0

~3 min read

Article

Liver failure is the inability of the liver to perform its normal synthetic and metabolic functions as part of normal physiology. Two forms are recognised, acute and chronic (cirrhosis). Recently, a third form of liver failure known as acute-on-chronic liver failure (ACLF) is increasingly being recognized.

Acute