LRRC4

Also known as NGL-2, NAG14, leucine rich repeat containing 4

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.

In the Vinony graph

Within Vinony's link graph, LRRC4 is referenced by 2 other articles, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 7 and LRR proteins.

Its subject is documented across 6 Wikipedia language editions.

Gene data

LRRC4

Name: leucine rich repeat containing 4
Type: protein-coding
Position: 127,938,259–128,032,280 (−)
Aliases: NAG14, NGL-2
Ensembl: ENSG00000128594
RefSeq RNA: NM_022143.5, XM_011516461.4, XM_047420695.1, XM_054358783.1, XM_054358784.1
RefSeq protein: NP_071426.1, XP_011514763.1, XP_047276651.1, XP_054214758.1, XP_054214759.1

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]

Gene Ontology

Biological process

modulation of chemical synaptic transmission postsynaptic density protein 95 clustering synaptic membrane adhesion synaptic membrane adhesion excitatory synapse assembly

Molecular function

protein binding cell-cell adhesion mediator activity

Cellular component

Golgi apparatus plasma membrane membrane postsynaptic membrane postsynaptic density membrane postsynaptic density membrane glutamatergic synapse glutamatergic synapse

Pathways

Axon guidance - Homo sapiens (human)Cell adhesion molecules - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

leucine rich repeat containing 4

Symbol: LRRC4
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:127,938,259-128,032,280
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein LRRC4 PDB 2dl9.png

Show 8 more facts

HomoloGene ID: 36403
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/64101
genomic end: 127672160
genomic start: 127667124
chromosome: human chromosome 7
cytogenetic location: 7q32.1
expressed in: cerebellar vermis

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. Also it has been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea. ==References==

Excerpted from Wikipedia’s “LRRC4” article, available under the CC BY-SA 4.0 licence.