LRRC8D
Sign in to saveAlso known as LRRC5, leucine-rich repeat containing 8 family member D, leucine rich repeat containing 8 family member D, leucine rich repeat containing 8 VRAC subunit D, HsLRRC8D
Leucine-rich repeat-containing protein 8D is a protein that in humans is encoded by the LRRC8D gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8E, is a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.
Gene data
LRRC8D- Name
- leucine rich repeat containing 8 VRAC subunit D
- Type
- protein-coding
- Position
- 89,820,978–89,936,611 (+)
- Aliases
- HsLRRC8D, LRRC5
- Ensembl
- ENSG00000171492
- RefSeq RNA
- NM_001134479.2, NM_018103.5, XM_011541689.2, XM_047423940.1, XM_047423943.1
- RefSeq protein
- NP_001127951.1, NP_060573.2, XP_011539991.1, XP_047279896.1, XP_047279899.1
Enables volume-sensitive anion channel activity. Involved in cellular response to osmotic stress; organic acid transport; and protein hexamerization. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. Part of ion channel complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
leucine rich repeat containing 8 VRAC subunit D
- Symbol
- LRRC8D
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:89,820,973-89,936,611
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 10004
- exact match
- identifiers.org/ncbigene/55144
- genomic end
- 90402170
- genomic start
- 90286573
- cytogenetic location
- 1p22.2
- Commons category
- LRRC8D
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Leucine-rich repeat-containing protein 8D is a protein that in humans is encoded by the LRRC8D gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8E, is a subunit of the heteromer protein Volume-Regulated Anion Channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.
While LRRC8D is one of many proteins that can be part of VRAC, it is in fact one of the most important subunits for the channel's ability to function; the other protein of importance is LRRC8A. However, while we know it is necessary for specific VRAC function, other studies have found that it is not sufficient for the full range of usual VRAC activity. This is where the other LRRC8 proteins come in, as the different composition of these subunits affects the range of specificity for VRACs.