LRRC8E
Sign in to saveAlso known as leucine rich repeat containing 8 family member E, leucine rich repeat containing 8 VRAC subunit E
Leucine-rich repeat-containing protein 8E is a protein that in humans is encoded by the LRRC8E gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8D, is sometimes a subunit of the heteromer protein volume-regulated anion channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.
Gene data
LRRC8E- Name
- leucine rich repeat containing 8 VRAC subunit E
- Type
- protein-coding
- Position
- 7,888,500–7,902,021 (+)
- Ensembl
- ENSG00000171017
- RefSeq RNA
- NM_001268284.3, NM_001268285.3, NM_025061.6, XM_011528319.3, XM_047439461.1
- RefSeq protein
- NP_001255213.1, NP_001255214.1, NP_079337.2, XP_011526621.1, XP_047295417.1
This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
leucine rich repeat containing 8 VRAC subunit E
- Symbol
- LRRC8E
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:7,888,500-7,902,021
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 11817
- exact match
- identifiers.org/ncbigene/80131
- genomic end
- 7966901
- genomic start
- 7953390
- cytogenetic location
- 19p13.2
- Commons category
- LRRC8E
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Leucine-rich repeat-containing protein 8E is a protein that in humans is encoded by the LRRC8E gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8D, is sometimes a subunit of the heteromer protein volume-regulated anion channel. Volume-Regulated Anion Channels (VRACs) are crucial to the regulation of cell size by transporting chloride ions and various organic osmolytes, such as taurine or glutamate, across the plasma membrane, and that is not the only function these channels have been linked to.
While LRRC8E is one of many proteins that can be part of VRAC, research has found that it is not as crucial to the activity of the channel in comparison to LRRC8A and LRRC8D. However, while we know that LRRC8A and LRRC8D are necessary for VRAC function, other studies have found that they are not sufficient for the full range of usual VRAC activity. This is where the other LRRC8 proteins come in, such as LRRC8E, as the different composition of these subunits affects the range of specificity for VRACs.