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mangafodipir
Sign in to saveMangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver, and has potential to serve as an adjunct for various chemotherapeutic agents and during coronary intervention. It has two parts, a paramagnetic manganese(II) ion and the fodipir (dipyridoxyl diphosphate, DPDP) chelating agent. When freed from the organic ligand, the manganese shortens the longitudinal relaxation time (T1) in an MRI scan. Normal liver tissue absorbs the manganese more than abnormal or cance
Chemical data
- Formula
- C22H32MnN4O14P2+2
- Molecular weight
- 693.4 g/mol
- IUPAC name
- 2-[2-[carboxymethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridinyl]methyl]amino]ethyl-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)-4-pyridinyl]methyl]amino]acetic acid;manganese(2+)
- SMILES
- CC1=NC=C(C(=C1O)CN(CCN(CC2=C(C(=NC=C2COP(=O)(O)O)C)O)CC(=O)O)CC(=O)O)COP(=O)(O)O.[Mn+2]
- InChIKey
- QDQFSBKXQQZVTB-UHFFFAOYSA-N
- Polar surface area
- 281 Ų
- H-bond donors
- 8
- H-bond acceptors
- 18
- Formal charge
- 2
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Has part
- manganese
- Mass
- 693.0759729041798
Show 2 more facts
- canonical SMILES
- CC1=NC=C(C(=C1O)CN(CCN(CC2=C(C(=NC=C2COP(=O)(O)O)C)O)CC(=O)O)CC(=O)O)COP(=O)(O)O.[Mn+2]
- chemical formula
- C₂₂H₃₂MnN₄O₁₄P₂²⁺
Sources (1)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- References
- External links
Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver, and has potential to serve as an adjunct for various chemotherapeutic agents and during coronary intervention. It has two parts, a paramagnetic manganese(II) ion and the fodipir (dipyridoxyl diphosphate, DPDP) chelating agent. When freed from the organic ligand, the manganese shortens the longitudinal relaxation time (T1) in an MRI scan. Normal liver tissue absorbs the manganese more than abnormal or cancerous tissue, which makes the normal tissue appear brighter in MRIs. This enhanced contrast allows lesions to be more easily identified.
Mangafodipir was withdrawn from the US market in 2003 and the European market in 2012 for commercial reasons by the manufacturer.
Excerpted from Wikipedia’s “mangafodipir” article, available under the CC BY-SA 4.0 licence.