Structure via PubChem · Public domain (PubChem)
manidipine
Sign in to saveManidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
Chemical data
- Formula
- C35H38N4O6
- Molecular weight
- 610.7 g/mol
- IUPAC name
- 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
- InChIKey
- ANEBWFXPVPTEET-UHFFFAOYSA-N
- XLogP
- 5.6
- Polar surface area
- 117 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, hypertension
via ChEMBL · EBI
Research
291 papers- Manidipine: a review of its use in the management of hypertension.Drugs · 2004
- Manidipine: a review of its use in hypertension.Drugs · 2001
- Antihypertensive effect of manidipine.Drugs · 2005
- Delapril/manidipine.Drugs · 2006
- Metabolic effects of manidipine.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2009
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 610.279
- Has use
- medication
Show 5 more facts
- defined daily dose
- 10
- chemical formula
- C₃₅H₃₈N₄O₆
- canonical SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
- subject has role
- calcium channel blocker
- Commons category
- Manidipine
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
It was patented in 1982 and approved for medical use in 1990.
Excerpted from Wikipedia’s “manidipine” article, available under the CC BY-SA 4.0 licence.